Tetradecylthioacetic Acid (TTA)
Tetradecylthioacetic Acid, otherwise known as TTA, is a PPAR-alpha activator. Although similar in structure to an omega-3 fatty acid, it cannot be utilized for energy and thus has no relevant caloric value to humans. PPAR-alpha is a transcription factor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation and is necessary for the process of ketogenesis, a key adaptive response to prolonged fasting.
Activation of PPAR-alpha promotes uptake, utilization, and catabolism of fatty acids by upregulation of genes involved in fatty acid transport, fatty acid binding, and activation, and peroxisomal and mitochondrial fatty acid. β-oxidation. The clearing of fat from the blood causes a drop in lipoproteins and a lowering of LDL cholesterol. TTA has also been shown to decrease blood pressure and exert a mild antioxidant effect.