RG3, Methylcobalamin, NAD+
RG3 is a Panax ginseng that has been used in oriental countries for its pharmacologic effects, such as antidiabetic, neurological, and anti-inflammatory activities. Neuroinflammation is associated with activation of the central nervous system (CNS) glia with significant cytokine and chemokine production, infiltration of immune cells, edema, increased blood-brain barrier (BBB) permeability and breakdown. Ginsenoside 20(S) RG3 is one of the many active ingredients of ginseng saponins. RG3 is a ginseng known for aiding chronic inflammation. Specifically, RG3 has been shown to reduce chronic neurodegenerative inflammation, the proinflammatory cytokine, interleukin-6 (IL-6) and interleukin-1β (IL-1β ), and tumor necrosis factor-α (TNF-α). Methylcobalamin and NAD+ are combined with RG3 to enhance its effects. Target treatments for RG3/Methylcobalamin/NAD+ include aging, traumatic brain injury (TBI), Alzheimer’s, diabetes, atherosclerosis, and hypertrophic scar formation. RG3 also has promising views for treatment in ovarian cancer, prostate cancer, and other cancers as well.