Glycyrrhetinic Acid & Aminophylline Transdermal Fat Loss Cream
Aminophylline and glycyrrhetinic acid transdermal cream are used for fat loss. Aminophylline and glycyrrhetinic prevent cAMP breakdown. Cyclic AMP (cAMP) functions in several biochemical processes including the regulation of glycogen, sugar, and lipid metabolism. cAMP works by activating protein kinase A (PKA) which assists in glycogen, sugar, and lipid metabolism. Aminophylline has displayed topical fat reduction from the waist. In a study examining aminophylline cream application, the reduction in waist circumference was significant for both men and women. Over a period of 12 weeks, participants in the study lost 11cm in waist circumference. In differentiated adipocytes, 18β-glycyrrhetinic acid increases the level of glycerol release and up-regulates the mRNA of hormone-sensitive lipase, adipose triglyceride lipase, and perilipin, as well as the phosphorylation of hormone-sensitive lipase. 18 β- glycyrrhetinic acid alters fat mass by directly affecting adipogenesis in maturing preadipocytes and lipolysis in mature adipocytes. Therefore, aminophylline and 18β- glycyrrhetinic acid may be useful for treating obesity. Both aminophylline and glycyrrhetinic acid combined effectively combat fat loss. Aminophylline and glycyrrhetinic acid fat loss cream yield the best results through topical application.