FGL(L) is a peptide with neurotrophic and memory enhancing properties. FGL peptide is a variant of the natural neural cell adhesion molecule. Neural cell adhesion molecule (NCAM) is a membrane-bound glycoprotein expressed on the surface of neuronal and glial cells. FGL(L) was directly created as a fibroblast growth factor receptor agonist.
FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1. Activating the NCAM–FGFR signaling pathways result in increased neurite outgrowth and survival and leads to its effects in memory. In addition to its effects on memory, FGL was found to have a positive impact on the healing of neuronal tissues subjected to ischemia by decreasing oxidative stress-induced neuronal cell death. FGL was also demonstrated to affect neuropathological symptoms related to Alzheimer’s disease by inhibiting neuronal degeneration and death.
Its potential effect on memory and neurodegenerative disease progression have excited many people and it was awarded a 60 million dollar grant in 2016 for further exploration. In addition to its effects on neurodegenerative disease, it also has been viewed as a targeted treatment for TBI, stroke, depression, and general improvement of cognitive function.


A Neural Cell Adhesion Molecule–Derived Fibroblast Growth Factor Receptor Agonist, the FGL-Peptide, Promotes Early Postnatal Sensorimotor Development and Enhances Social Memory Retention
Abstract—The neural cell adhesion molecule (NCAM) belongs to the immunoglobulin (Ig) superfamily and is composed extracellularly of five Ig-like and two fibronectin type III (F3) modules. It plays a pivotal role in neuronal development and synaptic plasticity. NCAM signals via direct interaction with the fibroblast growth factor receptor (FGFR). A 15-amino-acid long peptide, the FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1.
We here report that the FGL peptide, when administered intranasally to newborn rats, accelerated early postnatal development of coordination skills. In adult animals s.c. administration of FGL resulted in prolonged retention of social memory. We found that FGL rapidly penetrated into the blood and cerebrospinal fluid after both intranasal and s.c. administration and remained detectable in the fluids for up to 5 hours.

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